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Bupropion is used for treating depression.

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Bupropion is used for treating depression. Bupropion is an antidepressant. It works in the brain to treat depression.


Use Bupropion as directed by your doctor.

  • Take Bupropion by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Several weeks may pass before your symptoms improve. Do not stop taking Bupropion without checking with your doctor.
  • Take your doses at the same times each day, at least 6 hours apart unless directed otherwise by your doctor. This may help to decrease the risk of seizures with Bupropion.
  • Continue to take Bupropion even if you feel well. Do not miss any doses.
  • If you miss a dose of Bupropion, skip the missed dose and go back to your regular dosing schedule. Do not take more than 1 dose within 6 hours. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Bupropion.


Store Bupropion at room temperature, between 59 and 77 degrees F (15 and 25 degrees C), in a tight, light-resistant container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Bupropion out of the reach of children and away from pets.

Safety information

Do NOT use Bupropion if:

  • you are allergic to any ingredient in Bupropion
  • you are taking any other medicine that contains bupropion
  • you have a history of an eating disorder (eg, anorexia, bulimia) or seizures (eg, epilepsy)
  • you are suddenly stopping the use of alcohol or sedatives (eg, benzodiazepines) after long-term use
  • you are taking or have taken a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) within the last 14 days.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Bupropion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you or a family member has a history of bipolar disorder (manic depression), other mental or mood problems (eg, depression), suicidal thoughts or attempts, or alcohol or substance abuse
  • if you have diabetes, kidney problems, liver problems (eg, cirrhosis), high blood pressure, heart problems (eg, congestive heart failure), or a recent heart attack
  • if you have a history of seizures, head injury, or tumor in the brain or spinal cord.

Some medicines may interact with Bupropion. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Amantadine, antipsychotics (eg, haloperidol, risperidone), corticosteroids (eg, prednisone), cyclophosphamide, efavirenz, HIV protease inhibitors (eg, nelfinavir, ritonavir), insulin, levodopa, MAOIs (eg, phenelzine), nicotine patches, oral hypoglycemics (eg, glipizide), orphenadrine, other antidepressants (eg, amitriptyline, fluoxetine), sympathomimetics (eg, pseudoephedrine), theophylline, thiotepa, or tiagabine because they may increase the risk of Bupropions side effects
  • Carbamazepine, phenobarbital, phenytoin, or rifampin because they may decrease Bupropions effectiveness
  • Antiarrhythmics (eg, flecainide, propafenone), beta-blockers (eg, metoprolol), phenothiazines (eg, thioridazine), selective serotonin reuptake inhibitor (SSRI) antidepressants (eg, fluoxetine), or tricyclic antidepressants (eg, nortriptyline) because the risk of their side effects may be increased by Bupropion.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Bupropion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Bupropion may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Bupropion with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Check with your doctor before you drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Bupropion it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Bupropion may increase your risk of seizures. Your risk may be greater if you also have certain medical conditions, use certain medicines, or if you use a lot of alcohol. Talk to your doctor to see if you may have a greater risk of seizures while taking Bupropion.
  • If you already drink alcohol or use sedatives, do not suddenly stop them without first checking with your doctor. Suddenly stopping them may increase your seizure risk.
  • Do not take decongestants (eg, pseudoephedrine), stimulants, or diet pills while you are taking Bupropion without first checking with your doctor. They may increase your risk of seizures.
  • The risk of seizures may be greater if you take Bupropion in high doses or for a long time. Do NOT take more than the recommended dose, change your dose, or use Bupropion for longer than prescribed without checking with your doctor.
  • Children, teenagers, and young adults who take Bupropion may be at increased risk for suicidal thoughts or actions. Watch all patients who take Bupropion closely. Contact the doctor at once if new, worsened, or sudden symptoms such as depressed mood anxious, restless, or irritable behavior panic attacks or any unusual change in mood or behavior occur. Contact the doctor right away if any signs of suicidal thoughts or actions occur.
  • If you have trouble sleeping, you may be taking your dose too close to bedtime. Talk with your doctor about changing your dosing schedule.
  • Bupropion contains the same ingredients as Zyban, a medicine used to help stop smoking, and Aplenzin, another medicine used to treat depression. Do not take Bupropion if you are also taking Zyban or Aplenzin. Discuss any questions or concerns with your doctor.
  • Use Bupropion with caution in the elderly they may be more sensitive to its effects.
  • Bupropion should be used with extreme caution in children safety and effectiveness in children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Bupropion while you are pregnant. Bupropion is found in breast milk. Do not breast-feed while taking Bupropion.

Side effects

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Changes in appetite constipation dizziness drowsiness dry mouth headache increased sweating nausea nervousness restlessness taste changes trouble sleeping vomiting weight changes.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash hives itching difficulty breathing tightness in the chest swelling of the mouth, face, lips, or tongue, unusual hoarseness) blurred vision or other vision changes changes in sexual desire or ability chest pain confusion dark urine delusions fainting fast or irregular heartbeat fever, chills, or sore throat hallucinations hearing problems menstrual changes new or worsening mental or mood changes (eg, concentration problems, depression, panic attacks, aggressiveness, agitation, anxiety, impulsiveness, irritability, hostility, exaggerated feeling of well-being, inability to sit still) red, swollen, blistered, or peeling skin seizures severe headache or dizziness severe or persistent joint or muscle pain severe or persistent nausea, vomiting, or stomach pain severe or persistent nervousness, restlessness, or trouble sleeping shortness of breath suicidal thoughts or attempts tremor unusual swelling yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects.




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