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Active Ingredient: Sumatriptan

Imitrex is used to treat migraine headaches. Imitrex will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

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Imitrex is indicated for the acute treatment of migraine attacks with or without aura in adults. Imitrex is a headache medicine that narrows blood vessels around the brain. Imitrex also reduces substances in the body that can trigger headache pain, nausea, sensitivity to light and sound, and other migraine symptoms.


Use Imitrex exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Overuse of migraine headache medicine can actually make your headaches worse.

Use Imitrex as soon as you notice headache symptoms, or after an attack has already begun.

Your doctor may want to give your first dose of this medicine in a hospital or clinic setting to see if you have any serious side effects.

Take one Imitrex tablet whole with a full glass of water. Do not split the tablet.

After taking a tablet: If your headache does not completely go away, or goes away and comes back, take a second tablet two (2) hours after the first. Do not take more than 200 mg of sumatriptan oral tablets in 24 hours. If your symptoms have not improved, contact your doctor before taking any more tablets.

Since Imitrex is used as needed, it does not have a daily dosing schedule. Call your doctor promptly if your symptoms do not improve after using this medicine.

After taking a Imitrex tablet, you must wait two (2) hours before taking a second tablet. Do not take more than 200 mg of sumatriptan tablets in 24 hours.

After using Imitrex nasal spray, you must wait two (2) hours before using a second spray. Do not use more than 40 mg of nasal spray in 24 hours.

Contact your doctor if you have more than four headaches in one month (30 days).


In controlled clinical trials, single doses of 25, 50, or 100 mg of IMITREX Tablets were effective for the acute treatment of migraine in adults. There is evidence that doses of 50 and 100 mg may provide a greater effect than 25 mg.

The choice of dose should therefore be made on an individual basis, weighing the possible benefit of a higher dose with the potential for a greater risk of adverse events.

If the headache returns or the patient has a partial response to the initial dose, the dose may be repeated after 2 hours, not to exceed a total daily dose of 200 mg.


Store Imitrex at room temperature away from moisture, heat, and light.

Safety information

Do not use Imitrex within 24 hours before or after using another migraine headache medicine, including:

  • sumatriptan injection, almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt, Maxalt-MLT), or zolmitriptan (Zomig) or
  • ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, Cafergot, Migergot), dihydroergotamine (D.H.E. 45, Migranal), or methylergonovine (Methergine).

Imitrex may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

You should not use Imitrex if you are allergic to sumatriptan, or if you have:

  • coronary heart disease, angina (chest pain), blood circulation problems, lack of blood supply to the heart
  • a history of heart disease, heart attack, or stroke, including "mini-stroke"
  • severe or uncontrolled high blood pressure
  • severe liver disease
  • ischemic bowel disease or
  • a headache that seems different from your usual migraine headaches.

Do not use Imitrex if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days.

To make sure you can safely use Imitrex, tell your doctor if you have any of these other conditions:

  • liver disease
  • kidney disease
  • epilepsy or other seizure disorder
  • high blood pressure, a heart rhythm disorder or
  • coronary heart disease (or risk factors such as diabetes, menopause, smoking, being overweight, having high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

FDA pregnancy category C. It is not known whether Imitrex will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Sumatriptan can pass into breast milk and may harm a nursing baby. Do not breast-feed within 12 hours after using Imitrex. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby. Imitrex should not be given to anyone under 18 or over 65 years of age.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Imitrex: hives difficulty breathing swelling of your face, lips, tongue, or throat. Stop using Imitrex and call your doctor if you have a serious side effect such as:

  • feeling of pain or tightness in your jaw, neck, or throat
  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling
  • sudden numbness or weakness, especially on one side of the body
  • sudden severe headache, confusion, problems with vision, speech, or balance
  • sudden and severe stomach pain and bloody diarrhea
  • seizure (convulsions)
  • numbness or tingling and a pale or blue-colored appearance in your fingers or toes or
  • (if you are also taking an antidepressant) - agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.

Less serious Imitrex side effects may include:

  • mild headache (not a migraine)
  • pressure or heavy feeling in any part of your body
  • feeling hot or cold
  • dizziness, spinning sensation
  • drowsiness
  • nausea, vomiting, drooling
  • unusual taste in your mouth after using the nasal spray
  • burning, numbness, pain or other irritation in your nose or throat after using the nasal spray or
  • warmth, redness, or mild tingling under your skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.




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