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Active Ingredient: Olanzapine

Olanzapine is used for short-term treatment of agitation caused by schizophrenia or bipolar disorder.

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Olanzapine is an antipsychotic medication that affects chemicals in the brain.

Olanzapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults and children who are at least 13 years old.

Olanzapine is sometimes used together with other antipsychotic medications or antidepressants.

Olanzapine may also be used for purposes not listed in this medication guide.


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results.

Olanzapine can be taken with or without food.

Olanzapine is usually taken once a day. Olanzapine may be only part of a complete program of treatment that also includes counseling and other psychological support programs. Follow your doctors instructions.
Call your doctor if your symptoms do not improve, or if they get worse while using olanzapine. Do not stop taking olanzapine suddenly without first talking to your doctor, even if you feel fine. You may have serious side effects if you stop taking olanzapine suddenly.

To take olanzapine orally disintegrating tablets (Zyprexa Zydis):

Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil from the tablet blister. Do not push a tablet through the foil or you may damage the tablet.

Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve right away.

Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.

Swallow several times as the tablet dissolves. If desired, you may drink liquid to help swallow the dissolved tablet.

Olanzapine can cause high blood sugar (hyperglycemia). If you are diabetic, check your blood sugar levels on a regular basis while you are taking olanzapine.

You may gain weight or have high cholesterol and triglycerides (types of fat) while taking this medicine, especially if you are a teenager. Your blood may need to be tested often. Visit your doctor regularly.

If you are taking a combination of drugs, use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctors advice.


Take the medicine as prescribed by your doctor.


Store at room temperature away from moisture, heat, and light.


Active ingredient: Active ingredient:Olanzapine

Safety information

Olanzapine is not for use in psychotic conditions related to dementia. Olanzapine may cause heart failure, sudden death, or pneumonia in older adults with dementia-related conditions. You should not take olanzapine if you are allergic to it.

To make sure you can safely take olanzapine, tell your doctor if you have any of these other conditions:
liver disease

heart disease, high or low blood pressure

a history of low white blood cell (WBC) counts

high cholesterol or triglycerides

a history of heart failure, heart attack, or stroke

a history of breast cancer

seizures or epilepsy


an enlarged prostate or difficulty urinating

bowel problems or

narrow-angle glaucoma.

FDA pregnancy category C. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking olanzapine, do not stop taking it without your doctors advice. Olanzapine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using olanzapine.

The olanzapine orally disintegrating tablet (Zyprexa Zydis) may contain phenylalanine. Talk to your doctor before using this form of olanzapine if you have phenylketonuria (PKU).

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives difficulty breathing swelling of your face, lips, tongue, or throat. Stop using olanzapine and call your doctor at once if you have any of these serious side effects:

very stiff (rigid) muscles, high fever, tremors, sweating, confusion, fast or uneven heartbeats, slow heart rate, feeling like you might pass out

twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs

trouble speaking or swallowing

dry mouth, thirst, feeling very hot (with or without sweating), urinating less than usual or not at all

high blood sugar (increased thirst, loss of appetite, fruity breath odor, increased urination, drowsiness, dry skin, nausea, and vomiting)

sudden numbness or weakness, confusion, or problems with vision, speech, or balance

fever, chills, body aches, flu symptoms, sores in your mouth and throat

swelling in your hands or feet

changes in personality, unusual thoughts or behavior, hallucinations, or thoughts about hurting yourself or

upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

weight gain (more likely in teenagers), increased appetite

headache, dizziness, drowsiness, feeling tired or restless

memory problems

stomach pain, constipation, loss of bladder control

back pain, pain in your arms or legs

numbness or tingly feeling

breast swelling or discharge (in women or men) or

missed menstrual periods.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.




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