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Active Ingredient: Phenothiazine

Promethazine is used for relieving allergy symptoms, including hives or runny nose.

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Promethazine is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain. Promethazine also acts as an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.

Promethazine is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.

Promethazine also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.

Promethazine is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections.


Take promethazine exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Promethazine can be taken with or without food or milk.

Measure liquid medicine with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Call your doctor if your symptoms do not improve, or if they get worse while taking promethazine.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using promethazine.

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include severe drowsiness, dizziness, dry mouth, large pupils, flushing, nausea, vomiting, shallow breathing, and fainting.


Take it as prescribed by your doctor.


Store promethazine at room temperature away from moisture, heat, and light.


Active Ingredient: Promethazine

Safety information

Stop using promethazine and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects. Promethazine can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol, which can increase some of the side effects of promethazine. There are many other medicines that can interact with promethazine. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Important safety information:

Promethazine should not be given to a child younger than 2 years old. Promethazine can cause severe breathing problems or death in a child younger than 2. Carefully follow your doctors instructions when giving this medicine to a child of any age. Do not use this medication if you have severe asthma, emphysema, or other breathing problem, or if you are allergic to promethazine or other phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Permitil), perphenazine (Trilafon), prochlorperazine (Compazine, Compro), thioridazine (Mellaril), or trifluoperazine (Stelazine).

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you take promethazine, tell your doctor if you have:

a history of seizures

heart disease or high blood pressure

liver or kidney disease

severe asthma, emphysema, chronic obstructive pulmonary disease (COPD) or other breathing problem

sleep apnea (breathing stops during sleep)


a stomach ulcer or digestive obstruction

bone marrow depression

adrenal gland tumor (pheochromocytoma)

enlarged prostate or problems with urination

low levels of calcium in your blood (hypocalcemia) or

if you have ever had a serious side effect while using promethazine or any other phenothiazine.

FDA pregnancy category C. It is not known whether promethazine is harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether promethazine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from promethazine.

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives difficulty breathing swelling of your face, lips, tongue, or throat. Stop using promethazine and call your doctor at once if you have any of these serious side effects:

twitching, or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs

tremor (uncontrolled shaking), drooling, trouble swallowing, problems with balance or walking

feeling restless, jittery, or agitated

high fever, stiff muscles, confusion, sweating, fast or uneven heartbeats, rapid breathing

feeling like you might pass out

seizure (convulsions)

pale skin, easy bruising or bleeding, fever, sore throat, flu symptoms

decreased night vision, tunnel vision, watery eyes, increased sensitivity to light

hallucinations, agitation

nausea and stomach pain, skin rash, and jaundice (yellowing of the skin or eyes)

urinating less than usual or not at all

joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color or

slow heart rate, weak pulse, fainting, slow breathing (breathing may stop).

Less serious promethazine side effects may include:

dizziness, drowsiness, anxiety

blurred vision, dry mouth, stuffy nose

ringing in your ears

weight gain, swelling in your hands or feet

impotence, trouble having an orgasm or


This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect.




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