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Active Ingredient: fluticasone salmeterol

Seroflo Inhaler (Fluticasone/Salmeterol) is used for long-term prevention and treatment of asthma and chronic lung diseases.

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Seroflo Inhaler is used for long-term prevention and treatment of asthma and chronic lung diseases.


Use Seroflo Inhaler as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Seroflo Inhaler comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Seroflo Inhaler refilled. Do not use a spacer with Seroflo Inhaler.
Always ready and use this device in a level, flat position.
Hold the device in one hand and put the thumb of your other hand on the thumb grip. Push your thumb away from you as far as it will go until the mouthpiece appears and snaps into position.
Hold the device in a level, flat position with the mouthpiece toward you. Slide the lever away from you as far as it will go until it clicks.
Do NOT close or tilt the device, play with the lever, or move the lever more than 1 time. This may release or waste extra doses.
Hold the device away from your mouth and breathe out fully. Do NOT breathe into the inhaler. Put the mouthpiece to your lips. Breathe in quickly and deeply through the device.
Remove the device from your mouth. Hold your breath for about 10 seconds, or as long as is comfortable. Then breathe out slowly.
Close the device. Put your thumb on the thumb grip and slide it back toward you as far as it will go. The device will click shut and the lever will return to its original position.
Rinse your mouth with water after using Seroflo Inhaler. DO NOT swallow the rinse solution. Spit the rinse water out.
If you are using other inhaled medicines, wait a few minutes between using Seroflo Inhaler and other inhalers, unless directed otherwise by your doctor.
Take your doses of Seroflo Inhaler about 12 hours apart, unless your doctor tells you otherwise.
Never wash the mouthpiece or any other part of the inhaler. Keep it dry. Store Seroflo Inhaler in a dry place.
Throw Seroflo Inhaler away 1 month after you remove it from the foil pouch, or after the dose indicator reads "0," whichever comes first.
You may breathe more easily after the first dose of Seroflo Inhaler. However, it may take 1 week or longer to achieve the most benefit.
Use Seroflo Inhaler on a regular schedule to get the most benefit from it. Using Seroflo Inhaler at the same times each day will help you remember to use it. Do not stop using Seroflo Inhaler even if you feel better unless your doctor tells you to.


Store Seroflo Inhaler at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a dry place. Store away from direct heat and sunlight, moisture, and light. The inhalation device is not reusable and should be discarded 1 month after removal from the moisture-protective foil overwrap pouch or after all blisters have been used, whichever comes first.


Active Ingredients: Fluticasone and Salmeterol

Seroflo Inhaler is a long-acting corticosteroid and bronchodilator combination. It works by reducing inflammation and widening the airways in the lungs, which helps you breath more easily.

Safety information

Do NOT use Seroflo Inhaler if:
you are allergic to any ingredient in Seroflo Inhaler or to milk proteins you are having an asthma attack (eg, sudden, severe onset or worsening of asthma symptoms such as chest tightness, cough, shortness of breath, wheezing)
you are using another type of long-acting inhaled bronchodilator (eg, formoterol inhalation powder, salmeterol inhalation powder)
you are taking an azole antifungal (eg, ketoconazole), certain HIV protease inhibitors (eg, ritonavir), a macrolide antibiotic (eg, clarithromycin), nefazodone, or telithromycin
Contact your doctor or health care provider right away if any of these apply to you.
Some medical conditions may interact with Seroflo Inhaler. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
if you are pregnant, planning to become pregnant, or are breast-feeding
if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
if you have allergies to medicines, foods, or other substances
if you are taking a monoamine oxidase inhibitor (MAOI) (eg, phenelzine) or tricyclic antidepressant (eg, amitriptyline), or if you have taken either of these medicines within the last 14 days
if you have high blood acid levels (eg, ketoacidosis) or a history of diabetes, glaucoma, or increased pressure in the eye, heart problems (eg, fast or irregular heartbeat, heart blood vessel problems), high blood pressure, nervous system problems, liver problems, low blood potassium levels, seizures, thyroid problems, or an adrenal gland tumor
if you are having a COPD flare-up, have recently been to an emergency room for asthma, have a history of frequent hospitalizations for asthma, or have ever had a life-threatening asthma attack
if you have a fungal, bacterial, or parasitic infection a viral infection (eg, measles, chickenpox, shingles) herpes virus infection of the eye tuberculosis (TB) a history of a positive TB skin test or immune system problems or if you have had a recent vaccination
if you have weak bones (osteoporosis) or have risk factors for osteoporosis (eg, a family history of osteoporosis, tobacco use, long-term use of corticosteroids or certain seizure medicines, limited physical exercise, poor nutrition)
Some MEDICINES MAY INTERACT with Seroflo Inhaler. Tell your health care provider if you are taking any other medicines, especially any of the following:
Diuretics (eg, hydrochlorothiazide, furosemide) or long-acting inhaled bronchodilators (eg, salmeterol inhalation powder, formoterol inhalation powder) because the risk of low blood potassium or irregular heartbeat may be increased
Beta-blockers (eg, propranolol) because they may decrease Seroflo Inhaler effectiveness.
Azole antifungals (eg, ketoconazole), catechol-O-methyltransferase (COMT) inhibitors (eg, entacapone), delavirdine, HIV protease inhibitors (eg, ritonavir), macrolide antibiotics (eg, clarithromycin), MAOIs (eg, phenelzine), nefazodone, short-acting beta-agonist bronchodilators (eg, albuterol), telithromycin, or tricyclic antidepressants (eg, amitriptyline) because they may increase the risk of Seroflo Inhaler side effects

Side effects

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea dizziness headache mild muscle or bone pain nausea nervousness throat irritation tremor vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash hives itching difficulty breathing tightness in the chest swelling of the mouth, face, lips, or tongue)

behavior changes

blurred vision or other vision changes

chest pain


fast or irregular heartbeat


numbness or tingling in hands or feet


severe muscle weakness, cramps, or spasms

severe or persistent bone pain

severe or persistent dizziness or headache

signs of infection (eg, fever, chills, persistent headache/sore throat, ear pain, increased mucus production or change in mucus color)

swelling or tightness in the throat

trouble sleeping

unusual tiredness or weakness

vaginal odor or discharge

weight gain

white patches or sores on the tongue or mouth

worsening of asthma symptoms (eg, increased wheezing, coughing, chest tightness, shortness of breath).

More Information

Seroflo Inhaler is to be used only by the patient for whom it is prescribed. Do not share it with other people.




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