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Active Ingredient: Olanzapine

Zyprexa is used for treating schizophrenia or bipolar disorder.

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Zyprexa is used for treating schizophrenia or bipolar disorder. It is also used along with another medicine (fluoxetine) to treat certain types of depression. Zyprexa is an atypical antipsychotic.


Use Zyprexa as directed by your doctor.

  • Take Zyprexa by mouth with or without food.
  • Drinking extra fluids while you are taking Zyprexa is recommended. Check with your doctor for instructions.
  • Continue to take Zyprexa even if you feel well. Do not miss any dose.
  • If you miss a dose of Zyprexa, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Zyprexa.


Store Zyprexa at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Keep Zyprexa out of the reach of children and away from pets.


Active Ingredient: Olanzapine.

Safety information

Do NOT use Zyprexa if:

  • you are allergic to any ingredient in Zyprexa.

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Zyprexa. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a history of seizures, heart problems (eg, heart failure fast, slow, or irregular heartbeat), abnormal electrocardiogram (ECG), heart attack, stroke or mini-stroke, blood vessel problems, high blood cholesterol levels, high or low blood pressure, or low white blood cell levels
  • if you have a history of liver problems, stomach or bowel problems (eg, decreased muscle movement), enlarged prostate, narrow-angle glaucoma, neuroleptic malignant syndrome (NMS), aspiration pneumonia, or suicidal thoughts or attempts
  • if you have Alzheimer disease, bowel blockage, dementia, or trouble swallowing
  • if you have diabetes or are very overweight, or if a family member has had diabetes
  • if you have had high blood prolactin levels or a history of certain types of cancer (eg, breast, pancreas, pituitary), or if you are at risk for breast cancer
  • if you are dehydrated, drink alcohol, smoke, or you will be exposed to high temperatures.

Some medicines may interact with Zyprexa. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Alpha blockers (eg, doxazosin), diazepam, or medicine for high blood pressure because the risk of low blood pressure and fainting may be increased
  • Anticholinergics (eg, scopolamine), benzodiazepines (eg, lorazepam), or fluvoxamine because they may increase the risk of Zyprexas side effects
  • Carbamazepine, HIV protease inhibitors (eg, ritonavir), omeprazole, or rifampin because they may decrease Zyprexas effectiveness
  • Dopamine receptor agonists (eg, pramipexole) or levodopa because their effectiveness may be decreased by Zyprexa.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zyprexa may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Important safety information:

  • Zyprexa may cause dizziness, drowsiness, or decreased vision. These effects may be worse if you take it with alcohol or certain medicines. Use Zyprexa with caution. Do not drive or perform other possible unsafe tasks until you know how you react to it.
  • Do not drink alcohol while you are taking Zyprexa.
  • Talk with your doctor before you use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are taking Zyprexa it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Zyprexa may cause dizziness, lightheadedness, or fainting alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do not suddenly stop taking Zyprexa without checking with your doctor.
  • Do not become overheated in hot weather or while you are being active heatstroke may occur.
  • Zyprexa may raise your blood sugar. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away.
  • Zyprexa may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • NMS is a possibly fatal syndrome that can be caused by Zyprexa. Symptoms may include fever stiff muscles confusion abnormal thinking fast or irregular heartbeat and sweating. Contact your doctor at once if you have any of these symptoms.
  • Some patients who take Zyprexa may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Zyprexa in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms legs or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Zyprexa.
  • Lab tests, including fasting blood glucose, cholesterol, complete blood cell counts, and liver function, may be performed while you take Zyprexa. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Zyprexa with caution in the elderly they may be more sensitive to its effects, especially uncontrolled muscle movements.
  • Caution is advised when using Zyprexa in children they may be more sensitive to its effects, especially drowsiness, increased cholesterol and lipid levels, increased levels of prolactin (a hormone), and weight gain. Children may need regular weight checks while they take Zyprexa.
  • Zyprexa should be used with extreme caution in children younger 13 years safety and effectiveness in these children have not been confirmed.
  • Pregnancy and breast-feeding: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking Zyprexa while you are pregnant. Zyprexa is found in breast milk. Do not breastfeed while taking Zyprexa.

Side effects

All medicines may cause side effects, but many people have no, or minor, side effects.

Check with your doctor if any of these most common side effects persist or become bothersome:

Back or joint pain constipation cough dizziness drowsiness dry mouth increased appetite indigestion lightheadedness numbness or tingling of the skin restlessness sore throat weakness weight gain.

Seek medical attention right away if any of these severe side effects occur:

Severe allergic reactions (rash hives itching difficulty breathing tightness in the chest swelling of the mouth, face, lips, or tongue unusual hoarseness) abnormal thoughts chest pain confusion decreased urination fainting fast, slow, or irregular heartbeat fever, chills, or persistent sore throat increased saliva production or drooling increased sweating memory loss menstrual changes muscle pain, weakness, or stiffness new or worsening mental or mood changes (eg, depression, hallucinations) seizures severe or prolonged dizziness or headache shortness of breath suicidal thoughts or actions swelling of the hands, legs, or feet symptoms of high blood sugar (eg, increased thirst, hunger, urination unusual weakness) symptoms of high prolactin levels (eg , enlarged breast size, decreased sexual ability, missed menstrual period, nipple discharge) tremor trouble concentrating, speaking, or swallowing trouble sitting still trouble walking or standing uncontrolled muscle movements (eg, arm or leg movements, jerking or twisting, twitching of the face or tongue) unusual bruising vision changes yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.




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